ADH1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoADH1 (FOXG_07153) on chromosome 6 of Fusarium oxysporum f. sp. lycopersici 4287 encodes an aldo-keto reductase with NAD activity and zinc binding, containing ADH-like and PKS_ER domains. The gene is associated with the breakdown of acetaldehyde, ethanol, and threonine, as well as cellular response to farnesol. Its product localises to the cytoplasm, mitochondrial lumen, extracellular space, and fungal biofilm matrix. FoADH1 is linked to the related genes patD and alcC. Sequence similarity to related genes in other species places the encoded protein in the cinnamyl alcohol dehydrogenase (CAD) family, and studies of related fungal species connect this family to alcohol dehydrogenase (EC 1.1.1.1) activity.