ADH1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoADH1 (FOXG_06821) on chromosome 3 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a protein with aldo-keto reductase (NAD) activity and zinc binding, and contains ADH_Zn_CS, ADH-like_C, ADH-like_N, PKS_ER, GroES-like_sf, and NAD(P)-bd_dom_sf domains. The gene is associated with acetaldehyde breakdown, ethanol breakdown, threonine breakdown, and cellular response to farnesol. Its product localizes to the cytoplasm, mitochondrial lumen, extracellular space, and fungal biofilm matrix. FoADH1 is linked to the related genes patD and alcC. Related genes in other species, including Fusarium and Verticillium species, connect the family to alcohol metabolism (EC 1.1.1.1), though these specific associations are not yet established for FoADH1 itself.