FLBA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoFLBA (FLBA) on chromosome 3 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a regulator of G-protein signaling (RGS) protein with GTPase-activating protein (GAP) activity, containing DEP and RGS domains. The gene is associated with regulation of conidium formation, asexual sporulation, the pheromone response MAPK cascade, and both the breakdown and positive regulation of sterigmatocystin biosynthesis. It is linked to intracellular signal transduction, regulation of transcription by RNA polymerase II, and lipid metabolism. Phenotypic associations include abnormal mating response and pheromone sensitivity, altered shmoo formation, increased chemical compound excretion, and absence of osmotic stress resistance. The protein localizes to the cytoplasm, nucleus, and internal side of the plasma membrane. Related genes in other species connect this regulator to developmental control and oxidative stress response.