LAB5 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoLAB5 (FOXG_06134) on chromosome 2 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a lipoic acid synthase, a radical SAM enzyme with a Lipoyl_synth domain and 4Fe-4S cluster binding activity. The gene is associated with lipoate anabolism, protein lipoylation, and secretion, and its product localises to mitochondria. FoLAB5 is associated with abnormal peroxisomal morphology, petite colony formation, decreased nutrient utilization, abnormal mitochondrial genome maintenance, increased apoptosis, absent carbon source utilization, abnormal vegetative growth, decreased protein activity, increased filamentous growth, decreased biofilm formation, decreased carbon source utilization, decreased sporulation efficiency, increased protein activity, decreased rate of carbon source utilization, decreased respiratory growth, normal resistance to chemicals, decreased rate of respiratory growth, increased cold sensitivity, decreased acid pH resistance, increased stress resistance, decreased RNA accumulation, increased RNA accumulation, decreased protein/peptide modification, absent respiratory growth, auxotrophy, decreased innate thermotolerance, decreased heat sensitivity, increased oxidative stress resistance, and decreased desiccation resistance. Studies of related genes in other species link the lipoic acid synthase family to mitochondrial function and metal resistance.