HST1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoHST1 (FOXG_06210) on chromosome 2 of Fusarium oxysporum f. sp. lycopersici encodes a sirtuin-family NAD-dependent histone deacetylase with activity toward histones H3K4, H3K9, H3K14 and H4K16, and also acts as a transcription corepressor. The protein localises to nuclear lumen, chromatin, telomeric and subtelomeric heterochromatin, and the SET3C complex. FoHST1 is associated with epigenetic regulation of gene expression, heterochromatin assembly, centromeric and mating-type silencing, suppression of host immune responses, adhesion to host, phenotypic switching, regulation of thiamine anabolism, cell differentiation, fungal-type cell wall biogenesis, and response to oxygen levels. Phenotypic associations include increased virulence, flocculation, sporulation, cell cycle progression, oxidative stress resistance, nutrient uptake, and polyploidy. Related genes in other species link it to oxidative stress response.