LAC1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoLAC1 (FOXG_06109) on chromosome 2 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a protein with Lag1/Lac1-like, TRAM1, and TLC-dom domains. The gene is associated with ceramide synthase activity, ceramide anabolism, sphingolipid anabolism, detoxification, the meiotic cell cycle, and endocytosis, and its product localises to the endoplasmic reticulum membrane. FoLAC1 has been connected to the proteins FUM17, FUM18, and ALT7, and to expression patterns observed at 2 and 4 days post-inoculation in tomato. Studies of related genes in other Fusarium species link the family to ceramide synthase activity (EC 2.3.1.24) and to differential gene expression during tomato infection.