ERG2 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoERG2 (FOXG_01590) on chromosome 5 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a C-8 sterol isomerase, an ER membrane protein with isomerase activity. It is associated with ergosterol biosynthesis, translation elongation, and cellular response to xenobiotic stimulus. The gene is linked to numerous phenotypes including abnormal autophagy, cell cycle arrest, decreased mating response, increased cell death, and reduced nutrient uptake. It is also associated with shmoo formation, micronucleophagy, and plasma membrane morphology. Studies of related genes in other species link the family to reduced virulence and traits such as cell membrane stability, germination rate, and oxidative stress response.