SAR1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoSAR1 (FOXG_02298) on chromosome 5 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a small GTPase of the SAR1 family, possessing GTPase activity and GTP binding. The gene is associated with COPII vesicle coat formation, ER-to-Golgi transport, secretion, and vesicle organization, and its product localizes to the ER exit site, COPII vesicle membrane, Golgi membrane, and mitochondria-associated membrane. FoSAR1 is associated with abnormal Golgi morphology, absent protein secretion, defective cytokinesis, increased aneuploidy, altered cell cycle progression, and changes in nutrient uptake and carbon source utilization. It is also linked to increased lifespan, altered UV and X-ray resistance, and abnormal mitochondrial and nuclear envelope organization. Studies of related genes in other species link the family to unaffected pathogenicity and abnormal nuclear morphology.