frp1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FOXG_02927 (symbol frp1) on chromosome 8 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a ferric-chelate reductase (NADPH) with oxidoreductase activity acting on metal ions, NADH:Fe³⁺ oxidoreductase activity, and iron chelate reductase activity. The protein contains FAD-binding, NAD-binding, and transmembrane ferric reductase domains, binds FAD, iron, and other metals, and localises to the plasma membrane. It is associated with iron import into the cell, reductive iron assimilation, cellular response to iron starvation, iron homeostasis, copper ion import and membrane transport, carbon catabolite repression, filamentous growth, and spore formation. The gene is expressed during tomato infection at 2, 4, and 6 days post-inoculation. Related genes in other species link the family to reduced virulence and vascular wilt.