CDC42 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FOXG_03575 (CDC42) on chromosome 8 of Fusarium oxysporum f. sp. lycopersici encodes a small GTPase of the Rho family, possessing GTPase activity, GTP and GDP binding, protein serine/threonine kinase activator activity, and signaling adaptor activity. The gene is associated with the regulation of cell morphogenesis, bipolar and isotropic bud growth, cell wall modification, septin ring organization, and the positive regulation of 1,3-beta-D-glucan biosynthetic processes. It is linked to exocytic vesicles, the hyphal tip polarisome, the Spitzenkörper, and the 1,3-beta-glucan synthase complex. CDC42 is associated with the regulation of endocytic recycling, exocytosis, vesicle-mediated transport, and intracellular protein transport. Studies of related genes in other species link the family to virulence, including reduced virulence and loss of pathogenicity.