ALA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoALA (FOXG_03240) on chromosome 8 of Fusarium oxysporum f. sp. lycopersici 4287 encodes an ALAT1/2-like pyridoxal phosphate-dependent transaminase with L-alanine:2-oxoglutarate transaminase activity. The gene is associated with L-alanine and L-glutamate anabolism, L-alanine breakdown, and mycotoxin and fumonisin biosynthesis, and its product localises to the mitochondrial lumen. FoALA is associated with numerous phenotypes including decreased viability, abnormal cell cycle progression, altered vegetative growth, defective cytokinesis and septum formation, reduced gamma ray and ionic stress resistance, increased protein secretion, and abnormal mitochondrial genome maintenance. Related genes in other species link the family to nitrogen source utilisation, autophagy, and endoplasmic reticulum morphology, and sequence similarity links FoALA to alanine transaminase EC 2.6.1.2 and phosphate content traits.