FUM1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoFUM1 (FOXG_03085) on chromosome 8 of Fusarium oxysporum f. sp. lycopersici encodes a fumarate hydratase (EC 4.2.1.2), an enzyme of the fumarate lyase family that catalyses the reversible hydration of fumarate to malate. The gene is associated with the TCA cycle, fumarate and malate metabolism, and has been connected to fumonisin and mycotoxin anabolism. It is also linked to double-strand break repair and the DNA damage response. The product localises to the mitochondrial lumen, mitochondria, cytosol and nucleus. Expression of FoFUM1 has been detected during in vitro growth and at 2, 4 and 6 days post inoculation in tomato. Studies of related fumarase genes in other species have linked the family to seedling rot, though with no effect on pathogenicity.