AREA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoAREA (FOXG_03165) on chromosome 8 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a GATA-type transcription factor containing a Znf_GATA DNA-binding domain. The product is annotated with both DNA-binding transcription activator and repressor activity specific to RNA polymerase II, and sequence-specific DNA binding. FoAREA is associated with the regulation of nitrogen utilization, nitrate assimilation, arginine breakdown, and gene expression, as well as chromatin modeling. It localizes to the nucleus, cytoplasm, and cell division site. The gene is linked to numerous phenotypes including abnormal spore germination, increased pexophagy, altered autophagy, increased resistance to hydrostatic pressure, alkaline pH, cold, and osmotic stress, increased entry into G0 phase, increased pseudohyphal growth, decreased apoptosis, and altered cell cycle progression. Related genes in other species are linked to nitrate transport, nitrogen content, and virulence traits such as reduced or increased pathogenicity.