VAM7 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoVAM7 (FOXG_02319) on chromosome 5 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a syntaxin-family SNARE protein with a PX domain, with SNARE, SNARE-binding, and phosphoinositide-binding activity. The gene is associated with vacuole fusion, Golgi-to-vacuole transport, vesicle fusion, and intracellular protein transport, and its product localises to the SNARE complex, late endosome, endomembrane system, and fungal-type vacuole membrane. FoVAM7 is linked to abnormal micronucleophagy, absent vacuolar morphology, decreased endocytosis, increased hydrostatic pressure resistance, delayed sporulation, arrested mitotic cell cycle, abnormal meiotic recombination, increased entry into G0, absent budding, absent filamentous growth, absent protein secretion, absent mitophagy, and absent mating response. Sequence-similarity evidence connects the gene family to loss of pathogenicity and reduced virulence in other fungi, as well as to traits such as turgor pressure and calcium sensitivity.