SKP1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoSKP1 (FOXG_01898) on chromosome 5 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a member of the SKP1-like protein family, which contains a Skp1 component dimerisation and POZ domains and is associated with cullin family protein binding and ligase activity. The gene is linked to protein ubiquitination, ubiquitin-dependent proteolysis, and SCF-dependent proteasomal protein breakdown, as well as regulation of DNA recombination, resolution of meiotic recombination intermediates, mitotic cell cycle progression, and spore formation. Associations with phenotypes include altered cell cycle progression through G1/S and G2/M transitions, premature anaphase entry, decreased flocculation and adhesion, abnormal bipolar budding and pseudohyphal growth, delayed sporulation, and increased mating efficiency. The product localises to the cytoplasm, nucleus, RAVE complex, and ssDNA-dependent ATP-dependent DNA helicase complex. Studies of related genes in other species link the family to the nuclear SCF complex and loss of pathogenicity.