ARL1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FOXG_01899 (FoARL1, ARL1) on chromosome 5 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a small GTPase of the ARF/SAR family with GTP-binding, GTPase and G protein activity, and is associated with protein membrane adaptor function. The gene is associated with protein localization to the Golgi apparatus, vesicle organization, ER-to-Golgi transport, Golgi-to-plasma membrane transport, membrane organization, tubulin assembly, cell growth mode switching from monopolar to bipolar, regulation of mitotic cytokinesis, positive regulation of mitotic entry, and cellular responses to nitrogen starvation, heat, ER stress and AOS. It localizes to the COPII vesicle coat, ER exit site, TGN, microtubule cytoskeleton, division septum, cell cortex and PAS. Phenotypic associations include altered sporulation efficiency, increased virulence, decreased polyploidy, abnormal aneuploidy, absent biofilm formation, delayed protein transport, decreased endocytosis, increased alkaline pH and ionic stress resistance, and absent mitophagy. Related genes in other species link the family to reduced virulence.