ERF1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoERF1 (ERF1) on chromosome 5 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a eukaryotic peptide chain release factor subunit 1 (eRF1), possessing translation release factor activity, codon-specific release factor activity, peptidyl-tRNA hydrolase activity, GTPase regulator activity, and sequence-specific mRNA binding. The gene is associated with cytoplasmic translational termination, sno(s)RNA transcription, DNA-templated transcription termination, signal transduction, induced systemic resistance, and siderophore anabolism. Its product localises to the translation release factor complex, stress granules, the cytoplasm, and the cytosol. FoERF1 is linked to numerous phenotypes including abnormal filamentous growth, increased alkaline pH resistance, increased starvation resistance, increased desiccation resistance, increased vegetative growth rate, increased pseudohyphal growth, increased autophagy, and absent adhesion, endocytosis, and cytokinesis. Studies of related genes in other species link it to unaffected pathogenicity.