CNAB — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoCNAB (FOXG_01489) on chromosome 5 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a calcineurin B regulatory subunit, containing EF-hand calcium-binding domains and a calcineurin B domain. The gene product exhibits calcium-dependent protein serine/threonine phosphatase regulator and activator activities, and calcium ion binding. FoCNAB is associated with calcineurin-mediated signaling, calcium ion homeostasis, fungal-type cell wall organization, cellular thermotolerance, ER stress response, interaction with host, chlamydospore formation, and regulation of cell morphogenesis. It localizes to the calcineurin complex, cytoplasm, nucleus, and cell division site. Phenotypic associations link FoCNAB to abnormal cell cycle progression, filamentous growth, shmoo formation, cell fusion, hyperosmotic stress resistance, and pheromone sensitivity. Studies of related genes in other species connect the family to loss of pathogenicity and reduced virulence.