CPR2 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoCPR2 (FOXG_01453) on chromosome 5 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) that binds cyclosporin A and localises to the ER lumen, cytoplasm, membrane, fungal-type vacuole and extracellular space. The gene is associated with fumonisin and mycotoxin anabolism, protein folding, and abnormal colony colour, cell cycle arrest at metaphase-anaphase, delayed endocytosis, increased cell death, altered pseudohyphal and invasive growth, increased sporulation efficiency, and decreased osmotic stress resistance. It is also linked to altered respiratory metabolism, nutrient utilisation, protein transport, endomembrane system morphology, and increased mitophagy and prion formation. Related genes in other species are associated with reduced virulence and increased survival in stationary phase.