CHS3 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FOXG_00113 (CHS3, FoCHS3) on chromosome 1 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a chitin synthase with chitin synthase activity, containing chitin synthase, cytochrome b5-like heme/steroid-binding, and nucleotide-diphosphosugar transferase domains. The gene is associated with cell wall biogenesis, chitin anabolism, hyphal growth, asexual sporulation (conidia formation), ascospore wall assembly, and response to cellular mechanical stimulus. It localizes to the chitosome, plasma membrane, cross wall, incipient cellular bud site, cellular bud neck, and extracellular vesicles. Phenotypic associations include decreased septum formation, abnormal chitin deposition, abnormal spore wall formation, decreased adhesion, altered cell cycle progression (including G2 delay and metaphase-anaphase arrest), abnormal mating response, and increased alkaline pH resistance. Related genes in other species link the family to reduced virulence and polysaccharide content.