PEP1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoPEP1 (FOXG_00432) on chromosome 1 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a transmembrane signaling receptor with sortilin domains. The gene is associated with TGN-to-endosome transport, Golgi-to-vacuole transport, vacuolar protein sorting, and mating. It localizes to the Golgi complex, membrane, and cytosol. FoPEP1 is linked to numerous phenotypes including abnormal sporulation, increased necrotic cell death, absent pheromone sensitivity, sterile mating response, decreased cell fusion, and absent shmoo formation. It is also associated with delayed autophagy, decreased ribophagy, absent mitophagy, abnormal protein secretion, and decreased utilization of phosphorus sources. Related genes in other species connect the VPS10-sortilin family to vacuolar protein sorting and oxidative stress response.