NIT2 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoNIT2 (FOXG_00777) on chromosome 1 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a member of the C-N hydrolase superfamily with bis(5'-adenosyl)-triphosphatase and ω-amidase activities, acting on carbon-nitrogen bonds in linear amides. The gene is associated with nitrate assimilation, nitrate metabolism, glutamine metabolism, oxaloacetate metabolism, diadenosine triphosphate breakdown, and cellular detoxification. Its product localises to mitochondria, cytosol, and nucleus. Phenotypic associations link FoNIT2 to normal competitive fitness, absent respiratory growth, increased protein/peptide accumulation, decreased toxin resistance, abnormal and increased chemical compound accumulation, decreased competitive fitness, increased resistance to chemicals, and viability. Studies of related genes in other species connect the family to hydrolase activity.