CRL1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoCRL1 (FOXG_00764) on chromosome 1 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a small GTPase of the Rho family, possessing GTPase, GTP-binding, GDP-binding, protein serine/threonine kinase activator, and signaling adaptor activities. It is associated with the positive regulation of primary cell septum biogenesis, actomyosin contractile ring contraction, formin-nucleated actin cable assembly, septum digestion after cytokinesis, and 1,3-beta-D-glucan biosynthetic processes. The gene is linked to Rho protein signal transduction, regulation of division septum assembly, cell polarity establishment, bud growth, and hyphal tip growth. It localizes to the 1,3-beta-glucan synthase complex, hyphal tip, medial ring, and cell cortex. Related genes in other species link this gene family to loss of pathogenicity and reduced virulence.