AMT1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoAMT1 (FOXG_00426) on chromosome 1 of Fusarium oxysporum f. sp. lycopersici 4287 encodes an ammonium transporter family protein containing an AmtB-like domain and a Rhesus RHD domain, with molecular functions including ammonium channel activity and methylammonium transmembrane transporter activity. The gene is associated with ammonium import across the plasma membrane, methylammonium and ammonium membrane transport, and localisation to the plasma membrane, Golgi complex and fungal-type vacuole. FoAMT1 is associated with increased virulence, increased sporulation, abnormal biofilm formation, decreased nitrogen source utilisation, abnormal respiratory metabolism, increased necrotic cell death, altered cell cycle progression, and changes in autophagy and pexophagy. Related genes in other species link the ammonium transporter family to nitrogen source utilisation and filamentous growth.