PCN — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoPCN (FOXG_00337) on chromosome 1 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a proliferating cell nuclear antigen (PCNA), a DNA clamp that binds DNA. The gene is associated with DNA replication, including leading and lagging strand elongation, and with DNA repair pathways such as mismatch repair, error-free translesion synthesis, and UV excision repair. It is also linked to quorum sensing, secondary metabolism, and chromatin remodeling at double-strand breaks. The PCNA complex localises to the nucleus, nucleoplasm, chromatin, and replication forks. Phenotypic associations include delayed cell cycle progression through G1/S and S phases, delayed exponential growth, decreased budding, increased fermentative growth, and altered responses to X-ray and gamma-ray exposure. Studies of related genes in other species link the family to cell cycle regulation, DNA damage tolerance, and prion inheritance.