ARF1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoARF1 (FOXG_00379) on chromosome 1 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a small GTPase of the Arf1-5-like family with GTPase activity, GTP binding, G protein activity, and protein membrane adaptor functions. The gene is associated with vesicle organization, ER-to-Golgi transport, secretion, nuclear envelope and mitochondrial membrane organization, tubulin assembly, mitochondrial fission, cell growth mode switching, and regulation of mitotic cytokinesis. It is linked to the COPII vesicle coat, ER exit sites, microtubule cytoskeleton, division septum, and Golgi membrane. Phenotypic associations include absent sporulation and spore germination, decreased cell cycle progression, arrested mitosis, abnormal Golgi morphology, and reduced cell death. Related genes in other species link the family to reduced virulence.