afg2 — Fusarium culmorum CS7071

Summary

FCUL_08405.1 (AFG2) on chromosome 3 of Fusarium culmorum encodes a protein with ATP-dependent peptidase activity, metalloendopeptidase activity, protein disaggregase activity, protein transporter activity, and binds ATP, zinc, and polyubiquitin-modified proteins. It is associated with multiple protein quality control and degradation processes, including ubiquitin-dependent proteolysis, the proteasomal pathway, ribosome-associated ubiquitin-dependent protein breakdown, and protein dislocation from the endoplasmic reticulum. The gene is linked to ribosomal large subunit biogenesis and assembly, mitochondrial protein processing and quality control, the INMAD pathway, SREBP signalling, peroxisome matrix protein import and receptor recycling, mitotic spindle breakdown, and activation of the cellular response to hypoxic stress. It localises to the M-AAA complex, the p97-Ufd1-Npl4 complex, the RQC complex, the Hrd1p ubiquitin ligase complex, the Vms1-Cdc48-Npl4 complex, the peroxisome membrane, and the mitotic spindle midzone. Studies of related genes in other species, including PEX6 and PEX1, link the family to peroxisome biogenesis and AAA-type ATPase activity.