MCM7 — Fusarium culmorum CS7071

Summary

FCUL_10203.1 (MCM7) on chromosome 4 of Fusarium culmorum encodes a minichromosome maintenance (MCM) family protein with DNA helicase activity, ATP hydrolase activity, and H3-H4 histone carrier activity. The gene is associated with mitotic DNA replication initiation, pre-replicative complex assembly, DNA replication elongation, double-strand break repair via break-induced replication, and homologous recombination repair. It is also linked to chromatin binding, nucleosome binding, and replication-dependent chromatin assembly, as well as cell cycle phases including G1, S, and M phase. The MCM7 product localizes to the MCM complex, nuclear pre-replicative complex, replication fork, heterochromatin, and telomeric regions. Studies of related genes in other species link the MCM7 family to DNA replication origin binding and premeiotic DNA replication, though these associations are not established for F. culmorum.