FUR1 — Fusarium culmorum CS7071

Summary

FCUL_10615.1, designated FUR1 on chromosome 4 of Fusarium culmorum, encodes a protein with uracil phosphoribosyltransferase, uridine kinase, and cytidine kinase activities, and also binds ATP and GTP. The gene is associated with uracil, CTP, and UMP salvage pathways, as well as broader pyrimidine-containing compound salvage and pyrimidine base metabolism. It has also been connected to cell killing and secretion processes. The encoded protein localises to the mitotic spindle pole body, cell division site, cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to uracil salvage and uridine kinase activity. The protein contains a phosphoribosyltransferase domain.