VMA2 — Fusarium culmorum CS7071

Summary

FCUL_00685.1 (TUB1) on Fusarium culmorum chromosome 1 encodes a protein with structural constituent of cytoskeleton activity, GTP binding, and ATP binding, and belongs to the alpha-tubulin and tubulin/FtsZ families. It is associated with microtubule-based processes including microtubule assembly, destabilization, and dynamics, as well as nuclear migration by microtubule-mediated pushing forces, spindle positioning, chromosome separation, centromere localization, and the mitotic cell cycle. The gene is also linked to vacuolar acidification, ATP metabolism, and protein histidyl modification to diphthamide. It localizes to the microtubule, spindle, cytoplasm, nucleus, and plasmalemma. Studies of related genes in other species link the family to lethality when disrupted.