CLM2 — Fusarium culmorum CS7071

Summary

FCUL_01092.1 (ERG11) on chromosome 1 of Fusarium culmorum encodes a sterol 14-demethylase, a cytochrome P450 family protein with monooxygenase, oxidoreductase, and heme-iron binding activities. The gene is associated with ergosterol and steroid biosynthesis, demethylation, and mycotoxin production, as well as spore germination, sporulation, cytokinesis, cell growth, and fermentation. It is linked to sterol import, glycerol and heme anabolism, methylation, S phase, and homeostasis. The product localizes to the ER membrane. Studies of related genes in other species connect the ERG11 family to reduced virulence and lethality, and to oxidative stress responses.