URK1 — Fusarium culmorum CS7071

Summary

FCUL_02550.1 (URK1) on chromosome 1 of Fusarium culmorum encodes a protein with uracil phosphoribosyltransferase, uridine kinase, and cytidine kinase activities, and also binds ATP and GTP. The gene is associated with uracil, CTP, and UMP salvage pathways, as well as broader pyrimidine-containing compound salvage and pyrimidine base metabolism. Its product localises to the mitotic spindle pole body, cell division site, cytoplasm, cytosol, and nucleus. Studies of related genes in other species link this family to uracil phosphoribosyltransferase (EC 2.4.2.9) and uridine kinase (EC 2.7.1.48) activities. The protein belongs to the uridine kinase-like, PRK/URK, PRTase-like, and P-loop NTPase domain families.