MAC1 — Fusarium culmorum CS7071

Summary

FCUL_04237.1, symbol grisea, on chromosome 2 of Fusarium culmorum, encodes a DNA-binding transcription factor with RNA polymerase II-specific activity that also binds copper and zinc. The protein belongs to the copper homeostasis regulator (Copper_Homeo_Regul) family and contains a Cu_fist DNA-binding domain. It is associated with copper and iron ion homeostasis, detoxification, and both positive and negative regulation of transcription by RNA polymerase II. The product localises to the nucleus and cytoplasm. Studies of related genes in other species link this family to copper-responsive transcriptional regulation.