GLX3 — Fusarium culmorum CS7071

Summary

FCUL_05443.1 (symbol GLX3, also known as SNO4) on Fusarium culmorum chromosome 2 encodes a D-lactate dehydratase. The gene is associated with methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione, cellular thermotolerance, detoxification, response to oxidative stress, methylation, autophagy, homeostasis, and cell growth. Its product localises to the yeast-form and hyphal cell walls, fungal biofilm matrix, cytoplasm, cytosol, and nucleus. The encoded protein belongs to the DJ-1/PfpI and class I glutamine amidotransferase-like families. GLX3 is linked to oxidative stress. Studies of related genes in other species connect the family to loss of pathogenicity, though this has not been established in F. culmorum.