CLM2 — Fusarium culmorum CS7071

Summary

FCUL_06211.1 (ERG11, CYP51A) on chromosome 2 of Fusarium culmorum encodes a cytochrome P450 sterol 14-demethylase with monooxygenase, oxidoreductase, heme-binding and iron-binding activities. The gene is associated with ergosterol, sterol and steroid biosynthesis, as well as mycotoxin and heme production, glycerol anabolism, sporulation, spore germination, cytokinesis, S phase, cell growth, fermentation and homeostasis. The product localises to the endoplasmic reticulum membrane and other membranes. Studies of related genes in other species link the family to virulence and oxidative stress responses, and loss-of-function phenotypes include lethality and reduced virulence.