AFL1 — Fusarium culmorum CS7071

Summary

FCUL_07218.1 (VIP1, also known as asp1) on chromosome 3 of Fusarium culmorum encodes a protein with inositol hexakisphosphate 1-kinase activity, 5-diphosphoinositol pentakisphosphate 1-kinase activity, and related diphosphatase activities, along with ATP binding and 2Fe-2S cluster binding. The gene is associated with inositol phosphate metabolism and breakdown, intracellular Pi homeostasis, polyphosphate metabolism, and iron-sulfur cluster assembly. It is linked to the regulation of mitotic spindle elongation, bipolar cell growth, microtubule dynamics, and spindle assembly, as well as cell morphogenesis, invasive growth, nuclear import, protein kinase A signaling, and upregulation of glycolysis. The product localizes to the cytoskeleton, cytosol, and nucleus. Studies of related genes in other species link the family to inositol phosphate kinase activity (EC 2.7.4.24).