PPK6 — Fusarium culmorum CS7071

Summary

FCUL_10054.1, designated PSK1 on chromosome 4 of Fusarium culmorum, encodes a protein with protein serine/threonine kinase activity and protein kinase A activity. The gene is associated with the regulation of carbohydrate and glucose metabolism, including negative regulation of glycogen anabolism and upregulation of gluconeogenesis, as well as mycose catabolism. PSK1 is linked to cell cycle control, specifically positive regulation of the mitotic-to-meiotic switch and mitotic cytokinesis site selection, and to cell polarity establishment and growth mode switching from monopolar to bipolar. Associations also include fungal-type cell wall assembly, single-species surface biofilm formation, regulation of invasive growth in response to glucose limitation, and positive regulation of pseudohyphal growth. The encoded protein localises to growing and non-growing cell tips, the spindle midzone, and the cellular bud neck septin ring. Studies of related genes in other species link the family to oxidative stress response.