TOP1 — Fusarium culmorum CS7071

Summary

FCUL_09939.1 (TOP1) on chromosome 4 of Fusarium culmorum encodes a type I topoisomerase with DNA-binding and type I topoisomerase activity. The product belongs to the TopoI family and contains characteristic eukaryotic topoisomerase IB domains. This gene is associated with DNA topological change, DNA replication elongation, ribonucleotide excision repair, recombinational repair, and regulation of mitotic recombination. It is linked to asexual sporulation, cell differentiation, cell killing, mating-type switching, and class switching. Localisation evidence links the product to the nucleus, nucleolus, nucleoplasm, chromatin, chromosome, and cytosol. Studies of related genes in other species connect the family to reduced virulence.