CLM2 — Fusarium culmorum CS7071

Summary

FCUL_08966.1 (ERG11) on Fusarium culmorum chromosome 3 encodes a sterol 14-demethylase, a cytochrome P450 enzyme with monooxygenase, oxidoreductase, and heme-iron binding activities. This gene is associated with ergosterol and steroid biosynthesis, sterol import, and membrane localisation, particularly the ER membrane. It is also linked to spore germination, sporulation, cytokinesis, cell growth, S phase, fermentation, glycerol and heme anabolism, methylation, and homeostasis. Studies of related genes in other species link the family to oxidative stress responses, with loss-of-function phenotypes including reduced virulence and lethality.