CAG1 — Fusarium culmorum CS7071

Summary

GPA1 (FCUL_07707.1) on chromosome 3 of Fusarium culmorum encodes a G-protein alpha subunit, as indicated by its membership in the Gprotein_alpha_su and Fungi_Gprotein_alpha domain families. The product possesses GTPase activity, binds GTP and guanyl nucleotides, and interacts with G-protein-coupled receptors and beta/gamma-subunit complexes. It localises to the heterotrimeric G-protein complex and cytoplasm. GPA1 is associated with the regulation of sterigmatocystin, penicillin, and melanin biosynthesis, as well as conidium formation, sexual sporocarp development, seedling development, seed germination, cAMP metabolism, GPCR signalling, pheromone-dependent conjugation, maintenance of cell polarity, ruffle assembly, and response to iron. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence, though these effects are not established for F. culmorum itself.