RPB1 — Fusarium culmorum CS7071

Summary

FCUL_00994.1 (rpb1, RPO21) on Fusarium culmorum chromosome 1 encodes a protein with DNA-directed RNA polymerase activity, RdRP activity, DNA binding, metal binding, and a chromatin adaptor function. The product contains multiple RNA polymerase Rpb1 domains and a eukaryotic RNA polymerase II repeat. This gene is associated with transcription by all three RNA polymerases, including mRNA transcription, tRNA transcription, RNA elongation from Pol I and Pol II promoters, transcription initiation from Pol II and Pol III promoters, mRNA capping, and 3'-end processing. It is linked to co-transcriptional lncRNA cleavage and polyadenylation, TC-NER, bypass DNA synthesis, retrotransposition, intracellular phosphate homeostasis, and responses to UV and rapamycin. The protein localizes to RNA polymerase I, II, and III complexes, chromatin, nucleolus, mitochondria, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence and oxidative stress.