ACUD — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoACUD (FOXG_05529) on chromosome 7 of Fusarium oxysporum f. sp. lycopersici 4287 encodes an isocitrate lyase with methylisocitrate lyase activity and metal binding. The enzyme is associated with the glyoxylate cycle, TCA cycle, carbon catabolite repression, and the breakdown of acetate and fatty acids, and localises to the glyoxysome and peroxisome. The gene is linked to numerous phenotypes including increased hydrostatic pressure and alkaline pH resistance, decreased cold sensitivity and apoptosis, abnormal cell wall morphology, increased sporulation efficiency, and altered cell cycle progression. It is also associated with vegetative growth abnormalities, increased viability, and decreased mutation frequency. Studies of related genes in other species link isocitrate lyase to reduced virulence and survival in stationary phase, as well as to oxidative stress response and protein content.