SNF1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoSNF1 (FOXG_05528) on chromosome 7 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a serine/threonine protein kinase with protein kinase A activity, ATP binding, and phospholipid binding, containing SNF1_UBA, AMPK_C, and KA1/Ssp2_C domains. The gene is associated with the CAMKK-AMPK signaling cascade, cellular response to glucose starvation, regulation of invasive growth in response to glucose limitation, upregulation of gluconeogenesis and macroautophagy, and negative regulation of filamentous growth and pseudohyphal growth. It is linked to fungal-type cell wall assembly, septin ring assembly, single-species surface biofilm formation, and mycose catabolism. Localization evidence connects the product to the nucleotide-activated protein kinase complex, nuclear membrane, vacuolar membrane, and cellular bud neck. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.