RFT1 — Fusarium oxysporum Fo47

Summary

FoRFT1 (FOZG_10105) in Fusarium oxysporum Fo47 encodes a protein with glycolipid floppase activity, localized to the endoplasmic reticulum membrane. It is associated with glycolipid translocation, oligosaccharide-PP-dolichol assembly, and protein N-linked glycosylation. The gene is linked to abnormal cell cycle progression, cytokinesis, and meiosis, as well as decreased viability, sporulation, and filamentous growth. Associations also include abnormal protein secretion and transport, increased vegetative growth rate, increased carbon source utilization, and decreased resistance to X-ray and gamma ray. Additionally, FoRFT1 is linked to abnormal Golgi and endoplasmic reticulum morphology, increased mitophagy, and altered mutation frequencies. Studies of related genes in other species link the family to abnormal colony appearance.