CNH1 — Fusarium oxysporum Fo47

Summary

FoCNH1 (FOZG_11634) of Fusarium oxysporum Fo47 encodes a sodium:hydrogen exchanger with potassium transporter activity, belonging to the cation/H⁺ antiporter and Na⁺/H⁺ antiporter families. It is associated with sodium ion membrane transport, cellular potassium and sodium ion homeostasis, cell pH reduction, proton export across the plasma membrane, and regulation of membrane potential. The protein localises to the plasma membrane, cell tip, perinuclear ER membrane, and nuclear membrane-ER network. FoCNH1 is linked to numerous phenotypes including absent biofilm formation, arrested vegetative growth and exponential-phase growth, increased cell death, abnormal cell cycle progression through G2/M, increased desiccation and ionic stress resistance, and altered respiratory and fermentative metabolism. It is also associated with photosynthetic rate. Studies of related genes in other species link the family to sodium concentration, potassium content and uptake, and oxidative stress response.