SOD2 — Fusarium oxysporum Fo47

Summary

FoSOD2 (FOZG_16192) on chromosome JH717910 of Fusarium oxysporum Fo47 encodes a manganese/iron superoxide dismutase (Mn/Fe_SOD family) with superoxide dismutase activity and manganese binding, localised to the mitochondrial lumen, mitochondria and cytosol. The gene is associated with evasion or tolerance of host-produced reactive oxygen species, removal of superoxide radicals, and protein synthesis. It is linked to photosynthetic rate, as well as numerous phenotypes including increased necrotic cell death, abnormal spore wall and septum formation, increased freeze-thaw and hydrostatic pressure resistance, decreased radiation and pheromone sensitivity, and changes in cell cycle progression and stationary phase entry. Studies of related superoxide dismutase family members in other species connect the family to oxidative stress response, sodium and manganese content, and unaffected pathogenicity.