RPB1 — Fusarium oxysporum Fo47

Summary

FoRPB1 (FOZG_01635) of Fusarium oxysporum Fo47 encodes a protein containing RNA polymerase and DNA-directed RNA polymerase domains, and is annotated with DNA-directed RNA polymerase activity, DNA binding, metal binding, and chromatin adaptor functions. The gene is associated with transcription by RNA polymerases I, II, and III, including mRNA transcription, transcription initiation, elongation, termination, mRNA capping, co-transcriptional lncRNA 3' end processing, and RNA 3'-end formation. It is linked to bypass DNA synthesis, and localizes to the nucleus, nucleolus, chromatin, cytosol, and RNA polymerase I, II, and III complexes. Associations include increased virulence, altered cell cycle progression, sporulation, budding, cytokinesis, telomere length, killer toxin resistance, mitophagy, transposable element transposition, and pheromone sensitivity. Studies of related genes in other species link the family to reduced virulence, acid sensitivity, and oxidative stress response.