CP1 — Fusarium oxysporum Fo47

Summary

FoCP1 (FOZG_05323) on chromosome JH717898 of Fusarium oxysporum Fo47 encodes a serine carboxypeptidase, belonging to the peptidase S10 family with an AB hydrolase domain and a propeptide carboxypeptidase Y motif. Annotated serine carboxypeptidase activity and proteolysis are linked to this gene, and the product is localised to the fungal vacuole lumen. The gene is associated with diverse cellular processes, including abnormal autophagy, mitophagy, pexophagy, and ribophagy, as well as altered cell death, endocytosis, cytokinesis, nuclear fusion during mating, and protein secretion. Associations with increased acquired thermotolerance, altered prion inheritance, and changes in entry into stationary phase have also been recorded. Studies of related genes in other species link the family to serine carboxypeptidase EC 3.4.16.5 and apoplastic effector function.