CP1 — Fusarium oxysporum Fo47

Summary

FoCP1 (FOZG_08012) from Fusarium oxysporum Fo47 encodes a serine carboxypeptidase belonging to the peptidase S10 family, with serine carboxypeptidase activity. This gene is associated with proteolysis, zymogen activation, and protein catabolic processes in the vacuole, as well as phytochelatin anabolism and cellular response to nitrogen starvation. The encoded protein localizes to the fungal-type vacuole lumen and extracellular. FoCP1 is associated with numerous phenotypes including abnormal autophagy, altered cell death, increased aneuploidy, abnormal nuclear fusion during mating, and changes in prion inheritance, lifespan, and protein secretion. It is also linked to endocytosis, cytokinesis, and mitophagy. Studies of related genes in other species link the family to apoplastic effector functions.