RPB2 — Fusarium oxysporum Fo47

Summary

FoRPB2 (FOZG_10131) of Fusarium oxysporum Fo47 encodes a protein with multiple RNA polymerase Rpb2 domains and exhibits DNA-directed RNA polymerase, RNA-dependent RNA polymerase, ribonucleoside, RNA, DNA and zinc-binding activities. The encoded protein localises to the nucleus, cytosol, chromatin and centric heterochromatin, and is a component of RNA polymerase I, II and III complexes. FoRPB2 is associated with transcription initiation, elongation and termination from all three nuclear RNA polymerase promoters, snRNA transcription by RNA polymerase III, RNAi-mediated heterochromatin assembly at centromeres, and translation elongation. Phenotypic associations link the gene to abnormal cell cycle progression, meiosis, chromosome segregation, spore wall formation, shmoo formation, endocytosis, ribophagy, respiratory and fermentative metabolism, sulfur utilisation, transposable element transposition, silencing, aneuploidy, and decreased resistance to ionising radiation.